Ergone

Moderate

Ergostane-type steroid (ergosta-4,6,8(14),22-tetraen-3-one)

Mechanism of Action

Multifunctional steroidal metabolite exhibiting diuretic activity through modulation of renal tubular water and electrolyte transport—8-day administration produced diuretic effects equivalent to furosemide with significantly greater sodium, potassium, and chloride excretion. Demonstrates cytotoxic activity against hepatocellular carcinoma (HepG2), laryngeal carcinoma (Hep-2), and cervical carcinoma (HeLa) cell lines, with HepG2 showing greatest sensitivity. Also exhibits immunosuppressive activity and inhibits nitric oxide production in activated macrophages.

Research Notes

Zhu LingTCM

In vivo studies demonstrated ergone's diuretic potency equivalent to furosemide over 8-day dosing periods, with broader electrolyte excretion profile. In vitro cytotoxicity assays confirmed dose-dependent anti-proliferative effects against HepG2 > Hep-2 > HeLa cell lines. Ergone's dual immunosuppressive and diuretic properties distinguish it from the immunostimulatory polysaccharide fraction, creating a complex pharmacological profile within whole-extract preparations.

Found In 1 Herb

Zhu Ling

TCM

3D Molecular Structure

Ergostane-type steroid (ergosta-4,6,8(14),22-tetraen-3-one)

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Ergone

Ergostane-type steroid (ergosta-4,6,8(14),22-tetraen-3-one)Lipid-based molecules that regulate physiological processes

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

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