Epicatechin

Clinical trial

Mechanism of Action

Stimulates endothelial nitric oxide synthase (eNOS) to increase nitric oxide production; inhibits NADPH oxidase reducing oxidative stress; decreases platelet aggregation through inhibition of thromboxane synthesis; modulates NF-kB and Nrf2 pathways

Research Notes

CacaoSouth American

Epicatechin is one of the most extensively studied plant flavanols. The landmark Kuna Indian observational studies and numerous RCTs demonstrate significant improvements in flow-mediated dilation, blood pressure reduction (3-8 mmHg systolic), insulin sensitivity, and LDL oxidation resistance. The COSMOS trial (2022) with over 21,000 participants showed cardiovascular benefits of cocoa flavanol supplementation.

Found In 1 Herb

Cacao

South American

3D Molecular Structure

Flavanol (flavan-3-ol)

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Epicatechin

Flavanol (flavan-3-ol)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.