Embelin

In vitro / Animal

Mechanism of Action

Inhibits X-linked inhibitor of apoptosis protein (XIAP) by binding the BIR3 domain, promoting caspase-9-mediated apoptosis in parasitic organisms and abnormal cells. Also disrupts mitochondrial membrane potential in helminths, leading to paralysis and expulsion. Exhibits anti-inflammatory action through NF-kB pathway suppression and inhibition of 5-lipoxygenase.

Research Notes

VidangaAyurvedic

In vitro studies demonstrate potent anthelmintic activity against Ascaris lumbricoides, Pheretima posthuma, and various cestodes with paralysis and death at concentrations of 10–50 mg/mL. Animal studies confirm dose-dependent worm expulsion. Embelin has shown XIAP inhibitory activity (Ki ~4.1 microM) in cell-free and cell-based assays, with antitumor effects demonstrated against pancreatic, prostate, and breast cancer cell lines. A 2019 systematic review identified over 50 pharmacological activities attributed to embelin across preclinical models.

Found In 1 Herb

Vidanga

Ayurvedic

3D Molecular Structure

Alkyl-substituted hydroxybenzoquinone

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Embelin

Alkyl-substituted hydroxybenzoquinoneBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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