Eburicoic acid

In vitro

Mechanism of Action

Inhibits viral replication via suppression of host cell lipid biosynthesis pathways required for viral envelope assembly; demonstrates potent anti-inflammatory activity by inhibiting NF-κB nuclear translocation and downstream COX-2 expression. Also inhibits sterol 14α-demethylase (CYP51) in fungi and certain pathogens, contributing to antimicrobial activity.

Eburicoic acid exerts anti-inflammatory effects by regulating the PI3K/Akt/mTOR/NF-κB signaling pathway, resulting in inhibition of PGE2 (prostaglandin E2), COX-2 (cyclooxygenase-2), TNF-α, and IL-6 production. Hepatoprotective activity occurs through downregulation of inflammatory factors in liver tissue, modulation of antioxidant enzyme activity (SOD, catalase, glutathione peroxidase), and reduction of oxidative stress-mediated hepatocyte damage in acute liver injury models.

Research Notes

AgarikonMushroom

Eburicoic acid has been isolated from multiple Fomitopsis species and is one of the primary triterpenoids quantified in bioassay-guided antiviral fractionation of Agarikon. In vitro studies demonstrate inhibition of herpes simplex virus 1 and 2, influenza A, and poxvirus surrogates. Anti-inflammatory activity confirmed in LPS-stimulated macrophage models with IC50 values superior to several standard reference compounds. No clinical human data.

PoriaMushroom

In vivo studies demonstrated hepatoprotective effects in acute liver damage mouse models with significant reduction in serum transaminases (ALT, AST) and histological liver damage scores. Network pharmacology analysis of the Poria-Licorice herbal pair identified eburicoic acid as a key synergistic component. Anti-inflammatory activity confirmed in multiple acute and chronic inflammation models. No human clinical trials on isolated eburicoic acid.

Found In 2 Herbs

Agarikon

Mushroom

Poria

Mushroom

3D Molecular Structure

Lanostane triterpenoid (tetracyclic)

Drag to rotate · Click atoms to explore

Eburicoic acid

Lanostane triterpenoid (tetracyclic)Modified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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