Dietary nitrates

Clinical trial

Mechanism of Action

Sequential reduction to nitrite (NO2-) by oral commensal bacteria, then to nitric oxide (NO) in acidic gastric environment and tissues; NO activates soluble guanylyl cyclase, increasing cGMP and causing vascular smooth muscle relaxation

Research Notes

Beet RootWestern

Dietary nitrate from beet root juice is the most clinically validated natural nitric oxide precursor. Over 50 randomized controlled trials demonstrate consistent blood pressure reduction of 4-10 mmHg systolic. Meta-analyses confirm benefits for exercise economy, endurance performance, and vascular endothelial function. Effects are dose-dependent and attenuated by antibacterial mouthwash.

Found In 1 Herb

Beet Root

Western

3D Molecular Structure

Inorganic anion (NO3-)

Drag to rotate · Click atoms to explore

Dietary nitrates

Inorganic anion (NO3-)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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