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Delphinidin-3-glucoside

In vitro
Anthocyanin

Mechanism of Action

Antioxidant protection; reduces vascular endothelial inflammation and improves microcirculatory blood flow
Binds with high affinity to collagen fibers in vascular basement membranes, inhibiting collagenase and elastase to strengthen capillary wall integrity. Inhibits VEGF receptor-2 (VEGFR-2) phosphorylation, reducing pathological neovascularization. Accelerates rhodopsin regeneration in retinal rod photoreceptors by stabilizing the opsin-retinal Schiff base linkage and enhancing retinal pigment epithelium function.

Research Notes

BilberryWestern

Delphinidin-3-glucoside contributes to anthocyanin profile with strong antioxidant activity against vascular ROS. Supports capillary integrity through endothelial protective mechanisms. Secondary anthocyanin in bilberry.

BilberryWestern

Multiple controlled studies using standardized bilberry extract (Myrtocyan 36%) demonstrated significant improvements in retinal vascular parameters assessed by ophthalmoscopy and fluorescein angiography in patients with diabetic retinopathy. A 2021 systematic review of 12 RCTs found consistent improvements in contrast sensitivity, dark adaptation time, and visual acuity under low luminance conditions. Capillary fragility reduction has been documented in placebo-controlled trials in patients with chronic venous insufficiency.

Found In 2 Herbs

Bilberry

Bilberry

Western
Bilberry

Bilberry

Western

3D Molecular Structure

Anthocyanin
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Delphinidin-3-glucoside

AnthocyaninBioactive phytochemical with therapeutic properties

Representative pattern: C₁₅H₁₀O₃

Atoms
Carbon
Oxygen

Related Compounds (Anthocyanin)

Cyanidin-3-glucoside (C3G)(2)Delphinidin-based anthocyanins(1)Malvin (cyanidin-3,5-di-O-glucoside)(1)Protocyanin (cyanidin-3,5-diglucoside)(1)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.