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Delphinidin-3-glucoside
In vitroMechanism of Action
Antioxidant protection; reduces vascular endothelial inflammation and improves microcirculatory blood flow
Binds with high affinity to collagen fibers in vascular basement membranes, inhibiting collagenase and elastase to strengthen capillary wall integrity. Inhibits VEGF receptor-2 (VEGFR-2) phosphorylation, reducing pathological neovascularization. Accelerates rhodopsin regeneration in retinal rod photoreceptors by stabilizing the opsin-retinal Schiff base linkage and enhancing retinal pigment epithelium function.
Research Notes
BilberryWestern
Delphinidin-3-glucoside contributes to anthocyanin profile with strong antioxidant activity against vascular ROS. Supports capillary integrity through endothelial protective mechanisms. Secondary anthocyanin in bilberry.
BilberryWestern
Multiple controlled studies using standardized bilberry extract (Myrtocyan 36%) demonstrated significant improvements in retinal vascular parameters assessed by ophthalmoscopy and fluorescein angiography in patients with diabetic retinopathy. A 2021 systematic review of 12 RCTs found consistent improvements in contrast sensitivity, dark adaptation time, and visual acuity under low luminance conditions. Capillary fragility reduction has been documented in placebo-controlled trials in patients with chronic venous insufficiency.
Found In 2 Herbs
3D Molecular Structure
Anthocyanin
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Delphinidin-3-glucoside
AnthocyaninBioactive phytochemical with therapeutic properties
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Related Compounds (Anthocyanin)
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.