Davallialactone

In vitro / Animal

Mechanism of Action

Davallialactone is an oxygenated styrylpyrone that potently inhibits IkB kinase (IKK) activity, preventing the phosphorylation and degradation of IkBa and thereby blocking NF-kB nuclear translocation and transcriptional activation. This results in dose-dependent suppression of inflammatory mediators including TNF-alpha, IL-1beta, IL-6, prostaglandin E2 (PGE2), and nitric oxide (NO) in activated macrophages. Davallialactone also inhibits platelet aggregation through suppression of thromboxane A2 formation and may interfere with the arachidonic acid cascade via dual inhibition of COX and LOX enzymes.

Research Notes

Sang HuangMushroom

Davallialactone was identified in Phellinus species and demonstrated potent anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophage models, with IC50 values for NO inhibition in the low micromolar range. In vivo anti-inflammatory effects were confirmed in carrageenan-induced paw edema models in mice. Antiplatelet activity was demonstrated in human platelet-rich plasma, with inhibition of collagen-induced and ADP-induced aggregation. The compound has been proposed as a lead structure for development of novel anti-inflammatory and antithrombotic agents.

Found In 1 Herb

Sang Huang

Mushroom

3D Molecular Structure

Hypholomine-type styrylpyrone

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Davallialactone

Hypholomine-type styrylpyroneBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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