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Daidzein
ModerateMechanism of Action
Selective estrogen receptor modulator (SERM): binds preferentially to estrogen receptor beta (ERbeta) over ERalpha, producing tissue-selective estrogenic and anti-estrogenic effects. In bone, acts as an agonist promoting osteoblast differentiation and inhibiting osteoclast activity via RANKL suppression. Inhibits alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), potentially altering ethanol metabolism. Demonstrates antioxidant activity through radical scavenging and metal chelation.
Research Notes
Clinical trials of daidzein-rich isoflavone extracts for menopausal symptoms show modest benefits for hot flash frequency in some but not all studies. The equol hypothesis—that only individuals whose gut microbiota can convert daidzein to the more potent metabolite S-equol derive full benefit—has been supported by subgroup analyses. For alcohol-related effects, preclinical studies in alcohol-preferring rats show daidzin (the glycoside form) reduces voluntary ethanol intake by approximately 50%, mediated partly through ALDH2 inhibition.
Found In 1 Herb
3D Molecular Structure
Isoflavone (phytoestrogen)
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Daidzein
Isoflavone (phytoestrogen)Bioactive phytochemical with therapeutic properties
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Live Research
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