Daidzein

Moderate

Mechanism of Action

Selective estrogen receptor modulator (SERM): binds preferentially to estrogen receptor beta (ERbeta) over ERalpha, producing tissue-selective estrogenic and anti-estrogenic effects. In bone, acts as an agonist promoting osteoblast differentiation and inhibiting osteoclast activity via RANKL suppression. Inhibits alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), potentially altering ethanol metabolism. Demonstrates antioxidant activity through radical scavenging and metal chelation.

Research Notes

Kudzu Root (Ge Gen)TCM

Clinical trials of daidzein-rich isoflavone extracts for menopausal symptoms show modest benefits for hot flash frequency in some but not all studies. The equol hypothesis—that only individuals whose gut microbiota can convert daidzein to the more potent metabolite S-equol derive full benefit—has been supported by subgroup analyses. For alcohol-related effects, preclinical studies in alcohol-preferring rats show daidzin (the glycoside form) reduces voluntary ethanol intake by approximately 50%, mediated partly through ALDH2 inhibition.

Found In 1 Herb

Kudzu Root (Ge Gen)

TCM

3D Molecular Structure

Isoflavone (phytoestrogen)

Drag to rotate · Click atoms to explore

Daidzein

Isoflavone (phytoestrogen)Bioactive phytochemical with therapeutic properties

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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