Cytopiloyne

In vitro / Animal

Mechanism of Action

Modulates T-helper cell differentiation, promoting Th1 responses while suppressing Th2 polarization. Enhances insulin secretion from pancreatic beta cells through activation of the PLCγ1–PKCα signaling pathway. Also induces apoptosis in leukemia cell lines through mitochondrial pathway activation.

Research Notes

Picão PretoSouth American

A landmark 2007 study in the Journal of Ethnopharmacology demonstrated that cytopiloyne significantly enhanced glucose-stimulated insulin secretion in MIN6 beta cells and reduced blood glucose in diabetic mouse models. Immunological studies showed dose-dependent modulation of Th1/Th2 balance in human peripheral blood mononuclear cells. Anti-leukemic activity was demonstrated with IC50 of 0.1 μg/mL against HL-60 cells.

Found In 1 Herb

Picão Preto

South American

3D Molecular Structure

Polyacetylene

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Cytopiloyne

PolyacetyleneBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Related Compounds (Polyacetylene)

Falcarindiol(1)Falcarinol(1)

Live Research

Open on PubMed

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