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Cycloastragenol
StrongMechanism of Action
More bioavailable than astragaloside IV; activates telomerase via direct hTERT mRNA upregulation; reduces p16/p21 senescence markers in aging cells; extends replicative lifespan of T lymphocytes; antioxidant; anti-senescence via SIRT1 and FOXO pathway modulation
Research Notes
Cycloastragenol (TA-65) was the first natural compound demonstrated to activate telomerase and extend telomere length in vivo (Harley et al., 2011, Rejuvenation Research). A single-arm study showed increased mean telomere length and improved immune cell profiles over 12 months in healthy adults.
Found In 1 Herb
3D Molecular Structure
Cycloartane triterpenoid (aglycone of astragaloside IV)
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Cycloastragenol
Cycloartane triterpenoid (aglycone of astragaloside IV)Modified terpenes with diverse biological activities
Representative pattern: C₁₀H₁₆O
Atoms
Carbon
Oxygen
Hydrogen
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