Cycloastragenol

Strong

Cycloartane triterpenoid (aglycone of astragaloside IV)

Mechanism of Action

More bioavailable than astragaloside IV; activates telomerase via direct hTERT mRNA upregulation; reduces p16/p21 senescence markers in aging cells; extends replicative lifespan of T lymphocytes; antioxidant; anti-senescence via SIRT1 and FOXO pathway modulation

Research Notes

Astragalus (Huang Qi)TCM

Cycloastragenol (TA-65) was the first natural compound demonstrated to activate telomerase and extend telomere length in vivo (Harley et al., 2011, Rejuvenation Research). A single-arm study showed increased mean telomere length and improved immune cell profiles over 12 months in healthy adults.

Found In 1 Herb

Astragalus (Huang Qi)

TCM

3D Molecular Structure

Cycloartane triterpenoid (aglycone of astragaloside IV)

Drag to rotate · Click atoms to explore

Cycloastragenol

Cycloartane triterpenoid (aglycone of astragaloside IV)Modified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.