CVG (Coriolus versicolor glucan)

Preliminary

Mechanism of Action

CVG is a non-protein-bound beta-glucan fraction with a distinct molecular structure from PSK and PSP. It activates macrophage and dendritic cell responses through Dectin-1 receptor binding, promoting phagocytosis and reactive oxygen species (ROS) production. CVG also demonstrates significant prebiotic activity, serving as a fermentable substrate for commensal gut bacteria — particularly Bifidobacterium and Lactobacillus species — promoting eubiotic shifts in gut microbiome composition.

Research Notes

Turkey TailMushroom

Pallav et al. (2014, Gut Microbes, RCT, n=24) demonstrated that PSP/CVG fractions from T. versicolor produced consistent prebiotic-like changes in gut microbiome composition over 8 weeks, increasing Bifidobacterium and Lactobacillus populations while preventing the microbial disruption caused by antibiotics. The antibiotic comparison arm showed E. coli/Shigella overgrowth persisting 42+ days post-treatment, while the Turkey Tail arm maintained healthy microbiome diversity. In vitro studies show CVG enhances macrophage TNF-α and IL-6 production. Found in BOTH fruiting body and mycelium.

Found In 1 Herb

Turkey Tail

Mushroom

3D Molecular Structure

Beta-glucan (non-protein-bound)

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CVG (Coriolus versicolor glucan)

Beta-glucan (non-protein-bound)Immunomodulatory polysaccharides found in fungi and grains

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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