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Cucurbitacins B, E, and I
In vitroMechanism of Action
Potent cytotoxic, anti-inflammatory, and antimitotic activity; inhibit STAT3 signalling and induce apoptosis in cancer cell lines; contribute to gastrointestinal irritancy and systemic toxicity
Research Notes
ColocynthWestern
Extensively studied in vitro for anticancer activity via STAT3 inhibition and apoptosis induction. Responsible in part for the plant's extreme gastrointestinal irritancy. No human clinical trials for therapeutic applications.
Found In 1 Herb
3D Molecular Structure
Triterpenoid
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Cucurbitacins B, E, and I
TriterpenoidModified terpenes with diverse biological activities
Representative pattern: C₁₀H₁₆O
Atoms
Carbon
Oxygen
Hydrogen
Related Compounds (Triterpenoid)
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