Cucurbitacin R

Animal

Mechanism of Action

Inhibits prostaglandin synthesis through suppression of COX-2 expression and activity. Shows additional analgesic effects through modulation of vanilloid receptor (TRPV1) sensitivity, reducing neurogenic pain signaling.

Research Notes

TayuyaSouth American

Animal studies using the formalin test and carrageenan-induced paw edema model demonstrated significant analgesic and anti-inflammatory effects of cucurbitacin R from C. tayuya root extract. A 2004 study showed dose-dependent reduction in nociceptive behavior in the hot-plate test, supporting the traditional use for neuralgia and neuropathic pain.

Found In 1 Herb

Tayuya

South American

3D Molecular Structure

Tetracyclic triterpene (cucurbitane)

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Cucurbitacin R

Tetracyclic triterpene (cucurbitane)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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