Cucurbitacin B

In vitro / Animal

Mechanism of Action

Anti-inflammatory via STAT3 inhibition; anti-tumour; neuroprotective; antioxidant

Potent inhibitor of the JAK2/STAT3 signaling pathway, blocking STAT3 phosphorylation, nuclear translocation, and transcriptional activity. This suppresses expression of pro-inflammatory cytokines (IL-6, IL-17), anti-apoptotic proteins (Bcl-2, survivin), and proliferative genes (cyclin D1). Also disrupts actin cytoskeleton dynamics in cancer cells.

Research Notes

Kushmanda (Ash Gourd)Ayurvedic

Anti-inflammatory and neuroprotective effects in animal models. STAT3 inhibition has anti-tumour implications (research stage).

TayuyaSouth American

Cucurbitacin B has been extensively studied across multiple plant sources. IC50 for STAT3 inhibition ranges from 0.1–1 μM in various cancer cell lines. A 2009 study in Molecular Cancer Therapeutics demonstrated significant antitumor activity in xenograft mouse models of pancreatic cancer. Anti-inflammatory studies showed suppression of IL-6-mediated STAT3 activation in macrophages and synovial fibroblasts, supporting its use in inflammatory joint conditions.

Found In 2 Herbs

Kushmanda (Ash Gourd)

Ayurvedic

Tayuya

South American

3D Molecular Structure

Tetracyclic triterpenoid

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Cucurbitacin B

Tetracyclic triterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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