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Cordyceps militaris polysaccharides (CMP / beta-1,3/1,6-D-glucans)

Preliminary
High-molecular-weight beta-glucans

Mechanism of Action

CMP consists of β-(1→3)-linked glucose backbones with β-(1→6)-branch points, with a mean molecular weight of approximately 18.2 kDa for the linear fraction. These polysaccharides activate innate immune cells via Dectin-1 and TLR-2 receptor binding on macrophages and dendritic cells, upregulating NF-κB-mediated cytokine production. CMP also demonstrates significant anti-inflammatory activity through inhibition of NO and PGE2 production in LPS-stimulated macrophages. Mean beta-glucan content in cultured C. militaris is approximately 32.7% (w/w).

Research Notes

CordycepsMushroom

Structural characterization by Jo et al. (2022, International Journal of Molecular Sciences) identified a linear β-(1→3)-glucan of 18.2 kDa with anti-inflammatory properties in LPS-stimulated RAW264.7 macrophages. Bi et al. (2018, PLOS ONE) demonstrated that C. militaris β-glucans significantly reduced NO and PGE2 production in vitro. An animal study by Park et al. (2014) showed CMP enhanced NK cell activity and T-cell proliferation in immunosuppressed mice. Found in BOTH fruiting body and mycelium; hot-water extraction required for solubilization.

Found In 1 Herb

Cordyceps

Cordyceps

Mushroom

3D Molecular Structure

High-molecular-weight beta-glucans
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Cordyceps militaris polysaccharides (CMP / beta-1,3/1,6-D-glucans)

High-molecular-weight beta-glucansImmunomodulatory polysaccharides found in fungi and grains

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.