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Condurangin A and B (Condurango Glycosides)
In vitroMechanism of Action
Stimulate gastric acid secretion and bitter taste receptors (TAS2R) in the GI tract, promoting appetitive secretion reflexes; also inhibit topoisomerase II and induce apoptosis in certain cancer cell lines; at higher doses cause cardiac depression and CNS toxicity
Research Notes
CondurangoSouth American
Primary active constituents responsible for bitter tonic activity. Antineoplastic interest from in vitro studies showing topoisomerase II inhibition and apoptosis induction, but clinical evidence for anticancer activity remains inconclusive. Listed in German Commission E monographs as appetite-stimulating bitter.
Found In 1 Herb
3D Molecular Structure
Steroidal Glycoside (Pregnane)
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Condurangin A and B (Condurango Glycosides)
Steroidal Glycoside (Pregnane)Sugar-bound molecules that control drug release in the body
Representative pattern: C₂₁H₃₀O₂
Atoms
Carbon
Oxygen
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