Condurangin A and B (Condurango Glycosides)

In vitro

Mechanism of Action

Stimulate gastric acid secretion and bitter taste receptors (TAS2R) in the GI tract, promoting appetitive secretion reflexes; also inhibit topoisomerase II and induce apoptosis in certain cancer cell lines; at higher doses cause cardiac depression and CNS toxicity

Research Notes

CondurangoSouth American

Primary active constituents responsible for bitter tonic activity. Antineoplastic interest from in vitro studies showing topoisomerase II inhibition and apoptosis induction, but clinical evidence for anticancer activity remains inconclusive. Listed in German Commission E monographs as appetite-stimulating bitter.

Found In 1 Herb

Condurango

South American

3D Molecular Structure

Steroidal Glycoside (Pregnane)

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Condurangin A and B (Condurango Glycosides)

Steroidal Glycoside (Pregnane)Sugar-bound molecules that control drug release in the body

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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