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Colocynthin (Citrullol)
In vitro / AnimalMechanism of Action
Irritates intestinal mucosa, stimulates large bowel peristalsis, and increases enteric fluid and electrolyte secretion, producing watery catharsis and colic; also inhibits hepatic glucose output and activates PPAR-gamma in experimental models
Research Notes
ColocynthWestern
Identified as the primary cathartic principle in colocynth pulp. Antidiabetic effects observed in preclinical animal models through PPAR-gamma activation and hepatic glucose output inhibition. Limited human clinical data.
Found In 1 Herb
3D Molecular Structure
Triterpenoid Glycoside
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Colocynthin (Citrullol)
Triterpenoid GlycosideModified terpenes with diverse biological activities
Representative pattern: C₁₁H₁₄O₆
Atoms
Carbon
Oxygen
Live Research
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