Chlorogenic acid

Chlorogenic acid demonstrates complementary hepatoprotective activity. Inhibits hepatic lipid peroxidation and supports bile acid metabolism.

Clinical evidence from green coffee bean studies (high chlorogenic acid content) demonstrates modest fasting glucose and blood pressure reductions. Bilberry-specific data for chlorogenic acid effects on glycemia is limited but mechanistically plausible. Bioavailability studies show colonic microbiota-mediated conversion to ferulic and caffeic acids, which contribute to systemic antioxidant effects.

Chlorogenic acid is a well-characterised hydroxycinnamic acid with established antioxidant and antimicrobial properties.

Hepatoprotective and anti-inflammatory activity well documented across multiple plant sources. Antioxidant mechanism thoroughly characterised.

Hepatoprotective and antioxidant activity well established. High concentrations in Asteraceae thistle species support the bitter liver-tonic profile.

Reduces blood glucose post-prandially in clinical studies (from coffee research); anti-inflammatory; contributes to diaphoretic effect

Chlorogenic acid contributes antihypertensive and metabolic effects. Clinical evidence from leaf tea studies shows blood pressure and lipid-lowering benefits.

Well-documented antimicrobial and antioxidant properties. Major bioactive compound shared with Lonicera japonica.

Chlorogenic acid demonstrates anti-inflammatory, antioxidant, and preliminary hypoglycaemic activity. Supports traditional metabolic applications.

Reduced blood glucose in pre-diabetic subjects in clinical studies. Broad antiviral activity including influenza and herpes viruses. Anti-inflammatory via NF-kB and MAPK pathway suppression.

Chlorogenic acid from Ju Hua has been specifically studied in retinal pigment epithelial (RPE) cells, demonstrating protection against hydrogen peroxide-induced oxidative damage — providing pharmacological support for the traditional ophthalmological application. Shared antidiabetic and cardiovascular activities with Sang Ye chlorogenic acid. The presence of this compound in both Sang Ye and Ju Hua contributes to the synergistic activity of the Sang Ju Yin formula.

Extensively studied phenolic acid with strong antioxidant, anti-inflammatory, and hypoglycaemic activity.

Extensively studied phenolic acid with strong antioxidant and anti-inflammatory activity.

Supports liver uses noted in Culpeper; confirmed antioxidant in preclinical models.

Chlorogenic acid is one of the best-studied dietary polyphenols with consistent antidiabetic evidence across cell, animal, and human supplementation studies. Reduces fasting glucose and postprandial hyperglycemia in type 2 diabetes models. Meta-analysis of human studies documents modest but significant reductions in fasting blood glucose and insulin resistance markers.

Chlorogenic acid provides established antioxidant and hepatoprotective activity. Confirmed in related Sonchus arvensis.

Mate's high chlorogenic acid contributes to metabolic benefits. Clinical trials demonstrate reduced fasting glucose, improved lipid profiles, and anti-obesity effects.