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Cayaponoside
In vitroMechanism of Action
A glycosylated cucurbitacin with improved water solubility and reduced direct cytotoxicity compared to aglycone forms. Contributes to anti-inflammatory activity through NF-kB and MAPK pathway modulation. May serve as a prodrug, with the sugar moiety cleaved by intestinal glucosidases to release active cucurbitacin.
Research Notes
TayuyaSouth American
Identified and characterized from C. tayuya root by Brazilian researchers. In vitro anti-inflammatory assays showed inhibition of NO production in LPS-stimulated macrophages at concentrations less cytotoxic than cucurbitacin B, suggesting a potentially wider therapeutic window. The glycoside form showed better oral bioavailability in preliminary animal pharmacokinetic studies.
Found In 1 Herb
3D Molecular Structure
Cucurbitane glycoside
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Cayaponoside
Cucurbitane glycosideSugar-bound molecules that control drug release in the body
Representative pattern: C₁₁H₁₄O₆
Atoms
Carbon
Oxygen
Live Research
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