Canophylline

Animal

Sesquiterpene pyridine alkaloid (evonimine-type)

Mechanism of Action

Immunomodulatory activity via modulation of T-lymphocyte proliferation and cytokine production; anti-inflammatory through prostaglandin synthesis inhibition; mild analgesic properties attributed to peripheral opioid receptor partial agonism in animal pain models.

Research Notes

ChuchuhuasiSouth American

Canophylline and the related alkaloid canophyllidine are characteristic of Maytenus macrocarpa bark and contribute to its immunomodulatory and analgesic profile. In vitro lymphocyte proliferation assays show inhibition at micromolar concentrations. Peripheral analgesic activity demonstrated in hot-plate and writhing tests in mice. No human pharmacokinetic or clinical efficacy data available for isolated canophylline.

Found In 1 Herb

Chuchuhuasi

South American

3D Molecular Structure

Sesquiterpene pyridine alkaloid (evonimine-type)

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Canophylline

Sesquiterpene pyridine alkaloid (evonimine-type)Nitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

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