Back to Compound Explorer
Calycosin
PreliminaryMechanism of Action
ERβ agonist with slightly higher estrogenic activity than formononetin; anti-tumor via PTEN upregulation and PI3K/Akt pathway inhibition; cardioprotective via eNOS activation; promotes bone formation via osteoblast differentiation; neuroprotective in cerebral ischemia via Nrf2/HO-1 pathway
Research Notes
Higher ERβ binding affinity than formononetin (Kd ~0.5 nM). Anti-cancer activity against MCF-7, HCT116, and SGC-7901 cell lines. Neuroprotective effects in MCAO model with reduced infarct volume. Evidence primarily animal and in vitro.
Found In 1 Herb
3D Molecular Structure
Phytoestrogen isoflavone (3'-hydroxyformononetin)
Drag to rotate · Click atoms to explore
Calycosin
Phytoestrogen isoflavone (3'-hydroxyformononetin)Bioactive phytochemical with therapeutic properties
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Live Research
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.