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Calycosin
PreliminaryMechanism of Action
ERβ agonist with slightly higher estrogenic activity than formononetin; anti-tumor via PTEN upregulation and PI3K/Akt pathway inhibition; cardioprotective via eNOS activation; promotes bone formation via osteoblast differentiation; neuroprotective in cerebral ischemia via Nrf2/HO-1 pathway
Research Notes
Higher ERβ binding affinity than formononetin (Kd ~0.5 nM). Anti-cancer activity against MCF-7, HCT116, and SGC-7901 cell lines. Neuroprotective effects in MCAO model with reduced infarct volume. Evidence primarily animal and in vitro.
Found In 1 Herb
3D Molecular Structure
Phytoestrogen isoflavone (3'-hydroxyformononetin)
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Calycosin
Phytoestrogen isoflavone (3'-hydroxyformononetin)Bioactive phytochemical with therapeutic properties
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
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