Boldine

In vitro / Animal

Mechanism of Action

Potent antioxidant via direct radical scavenging and chelation of redox-active metals; inhibits lipid peroxidation in hepatic microsomes; stimulates bile secretion (choleretic effect) through enhanced biliary canalicular secretion; anti-inflammatory via inhibition of COX and LOX enzymes; antiplatelet via thromboxane A2 pathway antagonism; mild dopaminergic and α-adrenergic receptor antagonist activity.

Research Notes

BoldoSouth American

Boldine is the single most studied compound in boldo research. In vitro and rodent studies consistently demonstrate hepatoprotective activity against CCl4-induced liver damage, with significant reductions in ALT, AST, and oxidative stress markers. A small number of human pharmacokinetic studies confirm oral bioavailability and rapid hepatic distribution. Choleretic effects are well established in animal bile-fistula models. Antiplatelet activity observed in vitro warrants clinical monitoring with anticoagulant co-administration.

Found In 1 Herb

Boldo

South American

3D Molecular Structure

Aporphine alkaloid

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Boldine

Aporphine alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Aporphine alkaloid)

Magnoflorine(1)

Live Research

Open on PubMed

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