Blazein

Preliminary

Mechanism of Action

Blazein belongs to the blazeispirol class of des-A-ergostane-type steroid derivatives unique to Agaricus subrufescens. It induces apoptosis in tumor cell lines through activation of caspase-3 and caspase-9 in the intrinsic mitochondrial apoptotic pathway. Blazein also suppresses cell proliferation via p38 MAPK pathway activation and inhibits plasminogen activator, reducing tumor cell invasiveness and metastatic potential.

Research Notes

Royal Sun BlazeiMushroom

In vitro studies demonstrated blazein-induced apoptosis in human gastric cancer (TMK-1), lung cancer (A549), and hepatocellular carcinoma cell lines. Dose-dependent caspase activation was confirmed by Western blot analysis. Animal studies are limited, and no human clinical trials have been conducted specifically on isolated blazein.

Found In 1 Herb

Royal Sun Blazei

Mushroom

3D Molecular Structure

Steroid (des-A-ergostane derivative)

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Blazein

Steroid (des-A-ergostane derivative)Lipid-based molecules that regulate physiological processes

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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