Beta-1,3/1,6-D-glucans

Preliminary

Polysaccharides (high-molecular-weight beta-glucans)

Mechanism of Action

The beta-glucan fraction of H. erinaceus consists of β-(1→3)-linked glucose backbones with β-(1→6)-linked side chains. These polysaccharides activate innate immune responses through binding to Dectin-1 receptors on macrophages and dendritic cells, triggering NF-κB-mediated cytokine production (TNF-α, IL-6, IL-12). They also enhance intestinal immune function by modulating gut-associated lymphoid tissue (GALT) and promoting beneficial gut microbiota composition. Found in BOTH fruiting body and mycelium, though at higher concentrations in the fruiting body.

Research Notes

Lion's ManeMushroom

In vitro and animal studies have demonstrated that H. erinaceus polysaccharides enhance macrophage phagocytosis and NK cell activity (Sheng et al., 2017, International Journal of Biological Macromolecules). A 2017 animal study (Diling et al., International Journal of Molecular Sciences) showed that H. erinaceus polysaccharides modulated gut microbiota composition and improved intestinal mucosal immunity. Clinical data on immune endpoints remain limited to small pilot studies; the bulk of evidence is preclinical.

Found In 1 Herb

Lion's Mane

Mushroom

3D Molecular Structure

Polysaccharides (high-molecular-weight beta-glucans)

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Beta-1,3/1,6-D-glucans

Polysaccharides (high-molecular-weight beta-glucans)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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