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Atractylone

Preliminary
Sesquiterpene ketone

Mechanism of Action

Stimulates gastrointestinal motility through activation of motilin receptors (MLNR) in enteroendocrine cells and modulation of the enteric nervous system, accelerating gastric emptying and small intestinal transit. Demonstrates antifungal activity by disrupting fungal cell membrane ergosterol biosynthesis, inhibiting lanosterol 14α-demethylase (CYP51). Shows mild central nervous system sedative activity via potentiation of GABA-A receptor chloride conductance, consistent with Bai Zhu's traditional use in formulas for anxiety-associated digestive dysfunction.

Research Notes

Bai ZhuTCM

Animal studies have established dose-dependent gastroprokinetic effects of atractylone comparable to metoclopramide in delayed gastric emptying models using atropine-induced gastrointestinal suppression in rodents. Antifungal studies against Candida albicans, Candida tropicalis, and Aspergillus fumigatus report significant minimum inhibitory concentration (MIC) values at 8–32 μg/mL. Oral pharmacokinetic studies in rats suggest rapid intestinal absorption with peak plasma concentrations at 30–60 minutes and hepatic first-pass metabolism yielding multiple hydroxylated metabolites; human pharmacokinetic data remain limited.

Found In 1 Herb

Bai Zhu

Bai Zhu

TCM

3D Molecular Structure

Sesquiterpene ketone
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Atractylone

Sesquiterpene ketoneAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms
Carbon
Oxygen
Hydrogen

Related Compounds (Sesquiterpene ketone)

Ar-turmerone(1)Atlantone(1)beta-Turmerone(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.