Astragaloside IV

Preliminary

Mechanism of Action

Telomerase activation via upregulation of hTERT transcription; immunomodulatory via TLR-4 activation, NK cell enhancement, and T-cell proliferation; cardioprotective via PI3K/Akt/eNOS pathway; anti-fibrotic via TGF-β pathway suppression; neuroprotective via antioxidant and anti-apoptotic mechanisms; antidiabetic via AMPK activation and GLUT4 upregulation; anti-inflammatory via NF-κB inhibition

Research Notes

Astragalus (Huang Qi)TCM

hTERT upregulation and telomere elongation confirmed in CD8+ T cells and endothelial cells in vitro. Cardioprotective effects in ischemia-reperfusion models with reduced infarct size. Renal protective effects in diabetic nephropathy models. A Phase I/II clinical study demonstrated reduction in proteinuria in IgA nephropathy patients.

Found In 1 Herb

Astragalus (Huang Qi)

TCM

3D Molecular Structure

Cycloartane triterpenoid saponin

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Astragaloside IV

Cycloartane triterpenoid saponinModified terpenes with diverse biological activities

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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