Asperuloside

Preliminary

Iridoid glycoside (monoterpenoid glucoside)

Mechanism of Action

Asperuloside is an iridoid monoterpene glycoside whose primary biological activity is expressed upon hydrolysis to the aglycone asperulosidic acid by plant-endogenous beta-glucosidase enzymes (activated by cell disruption) and intestinal microflora. Asperulosidic acid inhibits prostaglandin biosynthesis through COX enzyme inhibition and suppresses NF-κB-mediated transcription of inflammatory cytokines. In vitro studies demonstrate inhibition of tumor cell proliferation via G2/M cell cycle arrest and induction of apoptosis through caspase-3 activation. The compound also exerts mild cathartic effects through stimulation of intestinal peristalsis. Asperuloside is relatively heat-labile and subject to significant loss upon prolonged drying or high-temperature extraction, supporting the traditional preference for fresh-plant preparations.

Bitter principle with mild laxative and diuretic properties; characteristic iridoid of Galium species

Research Notes

CleaversWestern

Asperuloside from Galium aparine and related Rubiaceae species has demonstrated anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, reducing TNF-α, IL-6, and NO production with IC50 values in the low micromolar range. Cytotoxic activity has been documented in HeLa, MCF-7, and HepG2 cancer cell lines with IC50 values of 20–80 µg/mL in MTT assays. In vivo anti-inflammatory data from rodent carrageenan models showed 25–35% reduction in paw edema at 100 mg/kg. No human clinical trials on isolated asperuloside from cleavers exist; efficacy data for the whole herb in its traditional lymphatic applications remain largely anecdotal.

Lady's BedstrawWestern

Characteristic iridoid glycoside of Galium species with mild laxative and diuretic properties.

Found In 2 Herbs

Cleavers

Western

Lady's Bedstraw

Western

3D Molecular Structure

Iridoid glycoside (monoterpenoid glucoside)

Drag to rotate · Click atoms to explore

Asperuloside

Iridoid glycoside (monoterpenoid glucoside)Modified terpenes with diverse biological activities

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.