Arbutin

Clinical trial

Mechanism of Action

Hydrolysed by intestinal flora and urinary beta-glucuronidase to release hydroquinone, which is antimicrobial in alkaline urine

Urinary antiseptic; converts to hydroquinone in alkaline urine

Glycoside of hydroquinone; mild antibacterial and skin-lightening agent found in pear skin

Hydrolyzed to hydroquinone in the urine; hydroquinone acts as urinary antiseptic with antimicrobial activity

Research Notes

Bearberry (Uva Ursi)Western

Arbutin provides direct urinary antiseptic effects against E. coli, Proteus, Pseudomonas, and Staphylococcus saprophyticus. Clinical trials support short-term use for uncomplicated UTI.

DamianaSouth American

Arbutin provides mild urinary antiseptic effects, supporting traditional use for urinary complaints.

Pear TreeWestern

Documented antibacterial activity. Used in dermatology for skin-lightening applications.

PipsissewaWestern

Primary active compound proposed for urinary antiseptic effect. In vitro studies demonstrate antimicrobial activity of hydroquinone. Traditional use supports efficacy but controlled clinical trials lacking. Efficacy dependent on urinary pH (alkaline urine favors antimicrobial effect) and individual metabolism.

Found In 4 Herbs

3D Molecular Structure

Hydroquinone glycoside

Drag to rotate · Click atoms to explore

Arbutin

Hydroquinone glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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