Arborinine

Preliminary

Mechanism of Action

Arborinine exhibits uterotonic activity by stimulating smooth muscle contractility through calcium channel modulation and prostaglandin synthesis enhancement in myometrial tissue. It also shows antimicrobial activity by intercalating into bacterial DNA and inhibiting topoisomerase II. Additionally, arborinine demonstrates antiplatelet effects through phosphodiesterase inhibition.

Research Notes

RueWestern

In vitro studies on isolated rat uterine tissue demonstrate dose-dependent contractile activity of arborinine and related Ruta alkaloids (Trovato et al., 2000). Antimicrobial screening shows activity against Staphylococcus aureus and Candida albicans with MIC values of 16–64 µg/mL. No clinical trials have been conducted with isolated arborinine; evidence is entirely preclinical.

Found In 1 Herb

Rue

Western

3D Molecular Structure

Acridone alkaloid

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Arborinine

Acridone alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

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