Applanoxidic acid A

Preliminary

Mechanism of Action

Novel polyoxygenated lanostane-type triterpenoid unique to G. applanatum. Disrupts bacterial and fungal cell membranes through direct interaction with membrane sterols. Exhibits selective antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus brevis) and the dermatophyte Trichophyton mentagrophytes. Also demonstrates cytotoxic activity against tumor cell lines through apoptosis induction.

Research Notes

Artist's ConkMushroom

Eight applanoxidic acids (A–H) have been isolated from G. applanatum fruiting bodies. In vitro studies published in Pharmaceuticals (2024) showed modified applanoxidic acids with activity against E. coli, S. aureus, Candida albicans, and T. mentagrophytes. The compounds are structurally distinct from the ganoderic acids of G. lucidum, representing a chemotaxonomic marker for the species.

Found In 1 Herb

Artist's Conk

Mushroom

3D Molecular Structure

Lanostanoid triterpene (polyoxygenated)

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Applanoxidic acid A

Lanostanoid triterpene (polyoxygenated)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

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