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Applanoxidic acid A
PreliminaryMechanism of Action
Novel polyoxygenated lanostane-type triterpenoid unique to G. applanatum. Disrupts bacterial and fungal cell membranes through direct interaction with membrane sterols. Exhibits selective antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus brevis) and the dermatophyte Trichophyton mentagrophytes. Also demonstrates cytotoxic activity against tumor cell lines through apoptosis induction.
Research Notes
Artist's ConkMushroom
Eight applanoxidic acids (A–H) have been isolated from G. applanatum fruiting bodies. In vitro studies published in Pharmaceuticals (2024) showed modified applanoxidic acids with activity against E. coli, S. aureus, Candida albicans, and T. mentagrophytes. The compounds are structurally distinct from the ganoderic acids of G. lucidum, representing a chemotaxonomic marker for the species.
Found In 1 Herb
3D Molecular Structure
Lanostanoid triterpene (polyoxygenated)
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Applanoxidic acid A
Lanostanoid triterpene (polyoxygenated)Aromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₁₀H₁₆O
Atoms
Carbon
Oxygen
Hydrogen
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