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Antroquinonol B

Animal
Tetrahydro-ubiquinone derivative

Mechanism of Action

Antroquinonol B exerts hepatoprotective effects through potent antioxidant mechanisms. It reduces malondialdehyde (MDA) content in liver tissue, indicating suppression of lipid peroxidation, while simultaneously increasing reduced glutathione (GSH) and total antioxidant capacity (T-AOC). At the signaling level, it inhibits phosphorylation of MAPK-related proteins p38 and JNK, preventing activation of pro-apoptotic and pro-inflammatory cascades in hepatocytes. This anti-apoptotic activity protects against chemical-induced acute liver injury by preserving mitochondrial membrane integrity and preventing caspase activation.

Research Notes

Antrodia / Niu Zhang ZhiMushroom

A 2025 study published in the Journal of Functional Foods demonstrated that antroquinonol B significantly reduced serum levels of ALT, AST, and AKP in a CCl4-induced acute liver injury mouse model, confirming in vivo hepatoprotective efficacy. The compound showed dose-dependent protection, with histological examination revealing preserved hepatocyte architecture and reduced inflammatory infiltration in treated animals. Additional in vitro studies have shown anti-inflammatory effects in Kupffer cells including reduced apoptosis and suppressed inflammatory cytokine secretion.

Found In 1 Herb

Antrodia / Niu Zhang Zhi

Antrodia / Niu Zhang Zhi

Mushroom

3D Molecular Structure

Tetrahydro-ubiquinone derivative
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Antroquinonol B

Tetrahydro-ubiquinone derivativeBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms
Carbon
Oxygen
Nitrogen
Hydrogen

Related Compounds (Tetrahydro-ubiquinone derivative)

Antroquinonol(1)

Live Research

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This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.