Alpha-hederin

Clinical trial

Monodesmosidic triterpene saponin (oleanane-type aglycone)

Mechanism of Action

Inhibits internalization and degradation of beta-2 adrenergic receptors on bronchial smooth muscle cells, increasing receptor surface density; stimulates surfactant production by type II alveolar cells through increased intracellular calcium signaling; reduces mucus viscosity

Research Notes

Ivy LeafWestern

Alpha-hederin is the key active metabolite of ivy leaf extract. The beta-2 receptor mechanism was demonstrated in airway epithelial cell studies published by Runkel et al. (2005). Clinical trials in over 65,000 patients across multiple countries demonstrate cough reduction comparable to synthetic mucolytics with excellent tolerability. Post-marketing surveillance confirms safety in children as young as 1 year.

Found In 1 Herb

Ivy Leaf

Western

3D Molecular Structure

Monodesmosidic triterpene saponin (oleanane-type aglycone)

Drag to rotate · Click atoms to explore

Alpha-hederin

Monodesmosidic triterpene saponin (oleanane-type aglycone)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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