Alisol B 23-Acetate

Preliminary

Protostane-type tetracyclic triterpenoid

Mechanism of Action

Inhibits hepatic lipid synthesis via HMG-CoA reductase inhibition; activates FXR (farnesoid X receptor) to regulate bile acid and cholesterol metabolism; induces hepatocyte autophagy to clear lipid droplets; anti-inflammatory via NF-κB pathway suppression

Research Notes

Ze Xie (泽泻)TCM

Alisol B 23-acetate demonstrates potent hypolipidemic effects in high-fat diet mouse models, reducing hepatic steatosis markers (ALT, AST, TG, TC) and improving liver histology. FXR agonist activity confirmed in vitro. Preliminary evidence for NAFLD management; human clinical trial data limited but growing in Chinese literature.

Found In 1 Herb

Ze Xie (泽泻)

TCM

3D Molecular Structure

Protostane-type tetracyclic triterpenoid

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Alisol B 23-Acetate

Protostane-type tetracyclic triterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Protostane-type tetracyclic triterpenoid)

Alisol A 24-Acetate(1)

Live Research

Open on PubMed

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