AHCC (Active Hexose Correlated Compound)

Clinical trial

Alpha-1,4-glucan-rich oligosaccharide (enzymatically processed mycelium extract)

Mechanism of Action

Unlike beta-glucan immunomodulators, AHCC acts primarily through alpha-glucan oligosaccharides (acetylated alpha-1,4-glucan, MW ~5000 Da). Activates NK cells and increases NK cell activity by 2–3 fold. Enhances dendritic cell number and function, increases cytokine production (TNF-α, IFN-γ, IL-12), and modulates T-cell populations (increases CD4+/CD8+ ratio). Also demonstrates CYP2D6 enzyme induction, which may affect drug metabolism.

Research Notes

ShiitakeMushroom

Over 100 published studies in PubMed. Ito et al. (2014) RCT (n=96) showed AHCC supplementation significantly enhanced NK cell activity in healthy adults (3 g/day × 4 weeks). Smith et al. (2014) RCT in HPV-positive women showed 63% HPV clearance rate with AHCC (3 g/day × 6 months) vs 34% placebo. Spierings et al. (2007) demonstrated safety and immunological activity in 20 cancer patients. Multiple Japanese observational studies in hepatocellular carcinoma show improved survival when AHCC is added to standard care.

Found In 1 Herb

Shiitake

Mushroom

3D Molecular Structure

Alpha-1,4-glucan-rich oligosaccharide (enzymatically processed mycelium extract)

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AHCC (Active Hexose Correlated Compound)

Alpha-1,4-glucan-rich oligosaccharide (enzymatically processed mycelium extract)Bioactive phytochemical with therapeutic properties

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.