Agaritine

Moderate

Aromatic hydrazine (phenylhydrazine derivative)

Mechanism of Action

Agaritine (β-N-[γ-L-glutamyl]-4-hydroxybenzylamine) is a potentially toxic compound that undergoes metabolic conversion to reactive diazonium intermediates capable of causing DNA strand scission and base oxidation. This mutagenic activity is oxygen-dependent and dose-related. Agaritine concentrations in commercial ABM products range from 112-1836 µg/g dry weight, with significant batch-to-batch variation. Degradation occurs over approximately 48 hours in tap water through oxidative decomposition.

Research Notes

Royal Sun BlazeiMushroom

Animal studies demonstrated carcinogenic, mutagenic, neurotoxic, hepatotoxic, and pulmonary toxic effects of agaritine and its metabolites. The Japanese Ministry of Health demanded recall of commercial products exceeding safety thresholds. A 2006 IARC review classified the evidence as limited. Human epidemiological studies of Agaricus bisporus consumers (which also contains agaritine at lower levels) have not shown increased cancer risk, but specific safety data for the higher concentrations found in A. subrufescens products are insufficient.

Found In 1 Herb

Royal Sun Blazei

Mushroom

3D Molecular Structure

Aromatic hydrazine (phenylhydrazine derivative)

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Agaritine

Aromatic hydrazine (phenylhydrazine derivative)Bioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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