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Aconitine → Benzoylaconine → Aconine
Meta-analysisMechanism of Action
Persistent Na+ channel activation → arrhythmia/cardiotoxicity; analgesic via Na+ channel modulation; anti-inflammatory. Processing converts toxic aconitine to less toxic derivatives
Research Notes
Raw aconitine LD50 ~0.1 mg/kg (extremely toxic). Processing (boiling/steaming) hydrolyses to benzoylaconine (100x less toxic) then aconine (1000x less toxic). Extended decoction critical for safety. Anti-inflammatory and analgesic in processed form.
Found In 1 Herb
3D Molecular Structure
Norditerpenoid alkaloid (C19-diterpenoid)
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Aconitine → Benzoylaconine → Aconine
Norditerpenoid alkaloid (C19-diterpenoid)Nitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
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