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8-Prenylnaringenin (8-PN)
ModerateMechanism of Action
Binds with high affinity to estrogen receptors ERα (Ki ~0.1 nM) and ERβ, with ERα selectivity. Activates classical estrogen response element (ERE)-mediated gene transcription and non-genomic MAPK/PI3K signaling downstream of membrane ERα. This translates to partial agonist/antagonist effects on estrogen-sensitive tissues depending on tissue estrogen environment, with agonist activity in estrogen-deficient states (menopause) and potential antagonist modulation in high-estrogen states.
Research Notes
HopsWestern
A randomized double-blind crossover study (n=67) using hops extract standardized to 8-PN demonstrated significant reduction in menopausal hot flush frequency and severity over 16 weeks. 8-PN demonstrates the highest estrogenic potency of any known plant compound, exceeding genistein by ~100-fold in receptor binding assays. Safety studies show no adverse effects on uterine or breast tissue in short-term (12-week) menopausal trials, though long-term safety in ER+ cancer contexts has not been adequately evaluated.
Found In 1 Herb
3D Molecular Structure
Prenylflavonoid (prenylated flavanone)
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8-Prenylnaringenin (8-PN)
Prenylflavonoid (prenylated flavanone)Polyphenolic antioxidants protecting cells from oxidative damage
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Live Research
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