5-Hydroxytryptophan (5-HTP)

Moderate

Aromatic amino acid / serotonin precursor

Mechanism of Action

Crosses the blood-brain barrier via large neutral amino acid transporters and is decarboxylated by aromatic L-amino acid decarboxylase (DOPA decarboxylase) to serotonin (5-HT) in both central and peripheral tissues; unlike L-tryptophan, bypasses rate-limiting tryptophan hydroxylase step, resulting in more reliable CNS serotonin elevation.

Research Notes

GriffoniaAfrican

Multiple double-blind placebo-controlled trials demonstrate efficacy of 5-HTP (150–300 mg/day) in mild-to-moderate depression comparable to certain SSRIs, with a more favourable side-effect profile. Evidence also supports benefit in fibromyalgia pain, migraine frequency reduction, and sleep architecture improvement including increased REM and slow-wave sleep.

Found In 1 Herb

Griffonia

African

3D Molecular Structure

Aromatic amino acid / serotonin precursor

Drag to rotate · Click atoms to explore

5-Hydroxytryptophan (5-HTP)

Aromatic amino acid / serotonin precursorBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.