3'-O-methylnordihydroguaiaretic acid

Clinical trial

Mechanism of Action

Enhanced lipoxygenase inhibition compared to NDGA; improved cellular uptake due to increased lipophilicity; selective inhibition of Sp1 transcription factor involved in tumor growth

Research Notes

ChaparralWestern

Methylated NDGA derivatives, including terameprocol (tetra-O-methyl NDGA), have advanced into clinical trials for cancer and viral infections. Phase I/II studies for recurrent high-grade glioma and HPV-related lesions have been conducted. These derivatives may offer therapeutic benefits of NDGA with improved safety profiles.

Found In 1 Herb

Chaparral

Western

3D Molecular Structure

Methylated lignan

Drag to rotate · Click atoms to explore

3'-O-methylnordihydroguaiaretic acid

Methylated lignanPlant polyphenols with antioxidant and estrogenic activity

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.