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2-Methyl-3-buten-2-ol (Methylbutenol)
PreliminaryMechanism of Action
Formed in vivo and ex vivo by microbial and chemical degradation of humulone during hops drying and gastrointestinal processing. Acts as a positive allosteric modulator of GABA-A receptors at the barbiturate binding site, reducing neuronal excitability. Inhalation during harvest produces rapid soporific effects via pulmonary absorption. The compound is structurally related to amylene hydrate, a historical surgical anesthetic.
Research Notes
HopsWestern
Animal studies demonstrate dose-dependent CNS depression, hypnosis, and reduced locomotor activity with methylbutenol administration. The compound has been detected in blood following consumption of hop-containing beverages. Human pharmacokinetic data is limited but consistent with significant bioavailability. The clinical significance of methylbutenol vs. other hops constituents to the observed sedative effects in human trials remains partially unresolved.
Found In 1 Herb
3D Molecular Structure
Tertiary alcohol (volatile degradation product of alpha-acids)
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2-Methyl-3-buten-2-ol (Methylbutenol)
Tertiary alcohol (volatile degradation product of alpha-acids)Bioactive phytochemical with therapeutic properties
Representative pattern: C₄H₂NO
Atoms
Carbon
Oxygen
Nitrogen
Hydrogen
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