Loading…
Back to Compound Explorer
1-Deoxynojirimycin (DNJ)
Clinical trialMechanism of Action
Potent alpha-glucosidase inhibitor, anti-diabetic, antiviral
Competitive inhibitor of intestinal alpha-glucosidases (maltase, sucrase, glucoamylase), reducing disaccharide hydrolysis and blunting postprandial glucose absorption; also inhibits hepatic glucokinase at higher concentrations; may modulate GLP-1 secretion
Research Notes
Potent alpha-glucosidase inhibition — basis for anti-diabetic use. Reduced postprandial glucose in human studies. Antiviral activity against several enveloped viruses.
Sang Ye (桑叶)TCM
Multiple RCTs (primarily in Japanese and Chinese literature) demonstrate significant reduction in postprandial blood glucose (15–30% reduction in glucose AUC) with standardized mulberry leaf preparations containing DNJ. Efficacy comparable to acarbose in some head-to-head studies, with improved GI tolerability. DNJ also demonstrated anti-HIV activity in vitro by inhibiting viral glycoprotein processing.
Found In 2 Herbs
3D Molecular Structure
Iminosugar / Piperidine alkaloid
Drag to rotate · Click atoms to explore
1-Deoxynojirimycin (DNJ)
Iminosugar / Piperidine alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Live Research
This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.